Mdm2

מתוך ויקיפדיה, האנציקלופדיה החופשית
קפיצה אל: ניווט, חיפוש
המבנה של mdm2

MDM2 הוא רגולטור שלילי חשוב של החלבון p53 שמונע גידולים. הוא השם של גם הגן וגם החלבון שהגן מקדד.

גילוי[עריכת קוד מקור | עריכה]

האונקוגן שמקדד את החלבון MDM2 שובט לראשונה, ביחד עם הגנים MDM1 ו-MDM3, משורת התאים העכבריים 3T3-DM. ביטוי יתר שלו, יחד עם Ras האונקוגני מניע התמרה של פיברובלסטים עכבריים, וביטוי של MDM2 גורם ליצירת גידולים בעכברים ערומים. לחלבון זה קיים הומולוג אנושי שלפעמים נקרא HDM2. אישוש לכך של-MDM2 יש חלק בהתפתחות גידולים, חוקרים מצאו רמות מוגברות של החלבון בסוגי סרטן מסוימים. MDM4, שלפעמים נקרא MDMX, הוא באותה משפחה של MDM2, וגם לו יש תפקיד כרגולטור שלילי של p53.

אינטראקציות[עריכת קוד מקור | עריכה]

המחקר הראה ש- MDM2 פועל ביחד עם HDAC1,[1] RPL26,[2] FKBP3,[3] CCNG1,[4] HTATIP,[5] GNL3,[6] Death associated protein 6,[7] PSME3,[8] Insulin-like growth factor 1 receptor,[9] RRM2B,[10] FOXO4,[11] Ribosomal protein L5,[6][12][13] Abl gene,[14] RYBP,[15] HIF1A,[16][17] PCAF,[18] TATA binding protein,[19][20] P73,[21][22] CTBP2,[23] NUMB,[24][25] P53,[26][27] P16,[7][12][28][29][30] PSMD10,[31] EP300,[32] CTBP1,[23] MDM4,[33][34][35][36] RPL11,[6][12] Promyelocytic leukemia protein,[37][38][39][40] Dihydrofolate reductase,[41] Arrestin beta 2,[42][43][44] Arrestin beta 1[43][44] ו- Ubiquitin C.[7][45][46]

מספר דרכים באפופטוזה של תאים

ראו גם[עריכת קוד מקור | עריכה]

לקריאה נוספת[עריכת קוד מקור | עריכה]

תבנית:PDB Gallery

הערות שוליים[עריכת קוד מקור | עריכה]

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