English: Figure 2. Schematic illustration of phototransduction mechanism and impacts of retinitis pigmentosa pathogenesis. In rod cells, light exposure induces transducer activation and subsequent phosphodiesterase (PDE) expression. PDE induces sodium channel closure. Rhodopsin (Rhodopsin*) and cyclic nucleotide-gate (CNG) ion channel mutations (CNGB*) alter rhodopsin signalization and are involved in retinitis pigmentosa pathogenesis. The figure was adapted from [98]. The Figure was partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license.