English: Main metabolic routes of MDMA (3,4-methyl​enedioxy​methamphetamine) racemic (R- and S-isomers = RS-) in humans. The most important cytochrome P450 enzymes enzymes are CYP2B6 and CYP2D6, less important enzymes are in brackets (e.g. CYP1A2). MDA route is a minor pathway.

• MDA: 3,4-methylenedioxyamphetamine
• HHA: 3,4-dihydroxyamphetamine
• HMA: 4-hydroxy-3-methoxyamphetamine
• HHMA: 3,4-dihydroxymethamphetamine
• HMMA: 4-hydroxy-3-methoxymethamphetamine
• COMT: catechol-O-methyltransferase

Based on sources:

• Luethi D et al. J Psychopharmacol. 2019. 33(7):831-841. doi:10.1177/0269881119844185. (p. 837)
• Steuer AE et al. PLoS One. 2016. 11(3):e0150955. doi:10.1371/journal.pone.0150955. PMC 4788153. (fig. 1)